Chromium picolinate

Research use only, not for human use.

Chromium picolinate causes DNA damage and mutation. It is an activator of p38.

Chromium picolinate is used to prevent chromium deficiency and to decrease serum glucose and insuline levels. It also decreases plasma lipid levels and platelet aggregation and improves myocardial contractility.

Cell Viability Assay Cell Line:lymphocytes Concentration:5,10, 25, 50, 75, 100 μM Incubation Time:24-72 h Result:Inhibited cell viability from concentration of 25 μM.Western Blot Analysis Cell Line:lymphocytes Concentration:50, 100 μM Incubation Time:24 h Result:Increased the expression of Bax. and cytochrome.Increased the activity of caspase-3.

Animal Model:Goto-Kakizaki diabetic rats Dosage:100 mg/kg Administration:p.o.Result:Increased body weight.The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats.Animal Model: Streptozotocin-induced diabetic rats Dosage:1 mg/kg.Administration:p.o.Result:Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats.Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.

CCRIS 8310 | CCRIS-8310 | Divista | Picolinic acid, chromium salt

Others

Other Targets

p38|DNA mutation

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14639-25-9

418.3

C18H12CrN3O6

>98% (HPLC)

In Vitro:?DMSO : 7.81 mg/mL (18.67 mM)

[Cr+3].[O-]C(=O)c1ccccn1.[O-]C(=O)c1ccccn1.[O-]C(=O)c1ccccn1

chromium(III) picolinate

(-20℃)

With Ice Pack

≥ 2 years